2026-02-17T17:10:09,211 Created temporary directory: /tmp/pip-ephem-wheel-cache-czql9jza
2026-02-17T17:10:09,213 Created temporary directory: /tmp/pip-build-tracker-vlicogt5
2026-02-17T17:10:09,214 Initialized build tracking at /tmp/pip-build-tracker-vlicogt5
2026-02-17T17:10:09,214 Created build tracker: /tmp/pip-build-tracker-vlicogt5
2026-02-17T17:10:09,215 Entered build tracker: /tmp/pip-build-tracker-vlicogt5
2026-02-17T17:10:09,216 Created temporary directory: /tmp/pip-wheel-le8jzde5
2026-02-17T17:10:09,219 DEPRECATION: --no-binary currently disables reading from the cache of locally built wheels. In the future --no-binary will not influence the wheel cache. pip 23.1 will enforce this behaviour change. A possible replacement is to use the --no-cache-dir option. You can use the flag --use-feature=no-binary-enable-wheel-cache to test the upcoming behaviour. Discussion can be found at https://github.com/pypa/pip/issues/11453
2026-02-17T17:10:09,221 Created temporary directory: /tmp/pip-ephem-wheel-cache-su7ohscd
2026-02-17T17:10:09,243 Looking in indexes: https://pypi.org/simple, https://www.piwheels.org/simple
2026-02-17T17:10:09,247 2 location(s) to search for versions of refua-clinical:
2026-02-17T17:10:09,247 * https://pypi.org/simple/refua-clinical/
2026-02-17T17:10:09,247 * https://www.piwheels.org/simple/refua-clinical/
2026-02-17T17:10:09,248 Fetching project page and analyzing links: https://pypi.org/simple/refua-clinical/
2026-02-17T17:10:09,249 Getting page https://pypi.org/simple/refua-clinical/
2026-02-17T17:10:09,250 Found index url https://pypi.org/simple
2026-02-17T17:10:09,461 Fetched page https://pypi.org/simple/refua-clinical/ as application/vnd.pypi.simple.v1+json
2026-02-17T17:10:09,462   Skipping link: No binaries permitted for refua-clinical: https://files.pythonhosted.org/packages/d3/09/1099b09fdc5667f97597d2513946ba54b9996ee1a9a8d93672b61f53bc9b/refua_clinical-0.2.0-py3-none-any.whl (from https://pypi.org/simple/refua-clinical/) (requires-python:<3.15,>=3.11)
2026-02-17T17:10:09,463   Found link https://files.pythonhosted.org/packages/bd/53/d8a3c8648b32e3af4e2a4bb64f9d7222a5bd7f6a85c286efd8939b3e9b19/refua_clinical-0.2.0.tar.gz (from https://pypi.org/simple/refua-clinical/) (requires-python:<3.15,>=3.11), version: 0.2.0
2026-02-17T17:10:09,464   Skipping link: No binaries permitted for refua-clinical: https://files.pythonhosted.org/packages/a7/44/273ef45ef3db2fcbc0939477dfd18318d48b3076e91572298a83ea23d50d/refua_clinical-0.6.0-py3-none-any.whl (from https://pypi.org/simple/refua-clinical/) (requires-python:<3.15,>=3.11)
2026-02-17T17:10:09,466   Found link https://files.pythonhosted.org/packages/6d/5b/1f643d8d2ba7a4d0fd0274cd3bf21754f5a4622991f86ea282120aebb8d9/refua_clinical-0.6.0.tar.gz (from https://pypi.org/simple/refua-clinical/) (requires-python:<3.15,>=3.11), version: 0.6.0
2026-02-17T17:10:09,467 Fetching project page and analyzing links: https://www.piwheels.org/simple/refua-clinical/
2026-02-17T17:10:09,467 Getting page https://www.piwheels.org/simple/refua-clinical/
2026-02-17T17:10:09,469 Found index url https://www.piwheels.org/simple
2026-02-17T17:10:09,632 Fetched page https://www.piwheels.org/simple/refua-clinical/ as text/html
2026-02-17T17:10:09,633   Skipping link: No binaries permitted for refua-clinical: https://www.piwheels.org/simple/refua-clinical/refua_clinical-0.2.0-py3-none-any.whl#sha256=403ce34c269264359dc4e7bdc695b91f05d2e0367c62416e0cabc0535937b104 (from https://www.piwheels.org/simple/refua-clinical/) (requires-python:<3.15,>=3.11)
2026-02-17T17:10:09,634 Skipping link: not a file: https://www.piwheels.org/simple/refua-clinical/
2026-02-17T17:10:09,635 Skipping link: not a file: https://pypi.org/simple/refua-clinical/
2026-02-17T17:10:09,655 Given no hashes to check 1 links for project 'refua-clinical': discarding no candidates
2026-02-17T17:10:09,675 Collecting refua-clinical==0.6.0
2026-02-17T17:10:09,677   Created temporary directory: /tmp/pip-unpack-j6ie08we
2026-02-17T17:10:09,886   Downloading refua_clinical-0.6.0.tar.gz (71 kB)
2026-02-17T17:10:10,055   Added refua-clinical==0.6.0 from https://files.pythonhosted.org/packages/6d/5b/1f643d8d2ba7a4d0fd0274cd3bf21754f5a4622991f86ea282120aebb8d9/refua_clinical-0.6.0.tar.gz to build tracker '/tmp/pip-build-tracker-vlicogt5'
2026-02-17T17:10:10,061   Created temporary directory: /tmp/pip-build-env-qi6w0ju0
2026-02-17T17:10:10,066   Installing build dependencies: started
2026-02-17T17:10:10,068   Running command pip subprocess to install build dependencies
2026-02-17T17:10:11,248   Using pip 23.0.1 from /usr/lib/python3/dist-packages/pip (python 3.11)
2026-02-17T17:10:11,808   DEPRECATION: --no-binary currently disables reading from the cache of locally built wheels. In the future --no-binary will not influence the wheel cache. pip 23.1 will enforce this behaviour change. A possible replacement is to use the --no-cache-dir option. You can use the flag --use-feature=no-binary-enable-wheel-cache to test the upcoming behaviour. Discussion can be found at https://github.com/pypa/pip/issues/11453
2026-02-17T17:10:11,831   Looking in indexes: https://pypi.org/simple, https://www.piwheels.org/simple
2026-02-17T17:10:13,674   Collecting setuptools>=68
2026-02-17T17:10:13,748     Using cached https://www.piwheels.org/simple/setuptools/setuptools-82.0.0-py3-none-any.whl (1.0 MB)
2026-02-17T17:10:14,021   Collecting wheel
2026-02-17T17:10:14,035     Using cached https://www.piwheels.org/simple/wheel/wheel-0.46.3-py3-none-any.whl (30 kB)
2026-02-17T17:10:14,261   Collecting packaging>=24.0
2026-02-17T17:10:14,279     Using cached https://www.piwheels.org/simple/packaging/packaging-26.0-py3-none-any.whl (74 kB)
2026-02-17T17:10:17,264   Installing collected packages: setuptools, packaging, wheel
2026-02-17T17:10:20,666     Creating /tmp/pip-build-env-qi6w0ju0/overlay/local/bin
2026-02-17T17:10:20,669     changing mode of /tmp/pip-build-env-qi6w0ju0/overlay/local/bin/wheel to 755
2026-02-17T17:10:20,691   Successfully installed packaging-26.0 setuptools-82.0.0 wheel-0.46.3
2026-02-17T17:10:20,972   Installing build dependencies: finished with status 'done'
2026-02-17T17:10:20,979   Getting requirements to build wheel: started
2026-02-17T17:10:20,980   Running command Getting requirements to build wheel
2026-02-17T17:10:21,697   running egg_info
2026-02-17T17:10:21,703   writing src/refua_clinical.egg-info/PKG-INFO
2026-02-17T17:10:21,710   writing dependency_links to src/refua_clinical.egg-info/dependency_links.txt
2026-02-17T17:10:21,712   writing entry points to src/refua_clinical.egg-info/entry_points.txt
2026-02-17T17:10:21,715   writing requirements to src/refua_clinical.egg-info/requires.txt
2026-02-17T17:10:21,717   writing top-level names to src/refua_clinical.egg-info/top_level.txt
2026-02-17T17:10:21,738   reading manifest file 'src/refua_clinical.egg-info/SOURCES.txt'
2026-02-17T17:10:21,742   reading manifest template 'MANIFEST.in'
2026-02-17T17:10:21,755   adding license file 'LICENSE'
2026-02-17T17:10:21,759   writing manifest file 'src/refua_clinical.egg-info/SOURCES.txt'
2026-02-17T17:10:21,857   Getting requirements to build wheel: finished with status 'done'
2026-02-17T17:10:21,860   Created temporary directory: /tmp/pip-modern-metadata-gz7qdcit
2026-02-17T17:10:21,862   Preparing metadata (pyproject.toml): started
2026-02-17T17:10:21,864   Running command Preparing metadata (pyproject.toml)
2026-02-17T17:10:22,525   running dist_info
2026-02-17T17:10:22,535   creating /tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info
2026-02-17T17:10:22,537   writing /tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info/PKG-INFO
2026-02-17T17:10:22,544   writing dependency_links to /tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info/dependency_links.txt
2026-02-17T17:10:22,546   writing entry points to /tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info/entry_points.txt
2026-02-17T17:10:22,549   writing requirements to /tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info/requires.txt
2026-02-17T17:10:22,550   writing top-level names to /tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info/top_level.txt
2026-02-17T17:10:22,552   writing manifest file '/tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info/SOURCES.txt'
2026-02-17T17:10:22,570   reading manifest file '/tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info/SOURCES.txt'
2026-02-17T17:10:22,572   reading manifest template 'MANIFEST.in'
2026-02-17T17:10:22,584   adding license file 'LICENSE'
2026-02-17T17:10:22,588   writing manifest file '/tmp/pip-modern-metadata-gz7qdcit/refua_clinical.egg-info/SOURCES.txt'
2026-02-17T17:10:22,589   creating '/tmp/pip-modern-metadata-gz7qdcit/refua_clinical-0.6.0.dist-info'
2026-02-17T17:10:22,714   Preparing metadata (pyproject.toml): finished with status 'done'
2026-02-17T17:10:22,719   Source in /tmp/pip-wheel-le8jzde5/refua-clinical_c38f7702ef1a4a7b8ce6003f774db3f4 has version 0.6.0, which satisfies requirement refua-clinical==0.6.0 from https://files.pythonhosted.org/packages/6d/5b/1f643d8d2ba7a4d0fd0274cd3bf21754f5a4622991f86ea282120aebb8d9/refua_clinical-0.6.0.tar.gz
2026-02-17T17:10:22,720   Removed refua-clinical==0.6.0 from https://files.pythonhosted.org/packages/6d/5b/1f643d8d2ba7a4d0fd0274cd3bf21754f5a4622991f86ea282120aebb8d9/refua_clinical-0.6.0.tar.gz from build tracker '/tmp/pip-build-tracker-vlicogt5'
2026-02-17T17:10:22,727 Created temporary directory: /tmp/pip-unpack-e77j4liv
2026-02-17T17:10:22,728 Building wheels for collected packages: refua-clinical
2026-02-17T17:10:22,732   Created temporary directory: /tmp/pip-wheel-tj4bqv6l
2026-02-17T17:10:22,733   Destination directory: /tmp/pip-wheel-tj4bqv6l
2026-02-17T17:10:22,735   Building wheel for refua-clinical (pyproject.toml): started
2026-02-17T17:10:22,736   Running command Building wheel for refua-clinical (pyproject.toml)
2026-02-17T17:10:23,362   running bdist_wheel
2026-02-17T17:10:23,379   running build
2026-02-17T17:10:23,380   running build_py
2026-02-17T17:10:23,386   creating build/lib/refua_clinical
2026-02-17T17:10:23,389   copying src/refua_clinical/models.py -> build/lib/refua_clinical
2026-02-17T17:10:23,391   copying src/refua_clinical/transportability.py -> build/lib/refua_clinical
2026-02-17T17:10:23,393   copying src/refua_clinical/voi.py -> build/lib/refua_clinical
2026-02-17T17:10:23,395   copying src/refua_clinical/admet_integration.py -> build/lib/refua_clinical
2026-02-17T17:10:23,397   copying src/refua_clinical/cli.py -> build/lib/refua_clinical
2026-02-17T17:10:23,400   copying src/refua_clinical/explainability.py -> build/lib/refua_clinical
2026-02-17T17:10:23,403   copying src/refua_clinical/integrations.py -> build/lib/refua_clinical
2026-02-17T17:10:23,405   copying src/refua_clinical/__main__.py -> build/lib/refua_clinical
2026-02-17T17:10:23,407   copying src/refua_clinical/optimization.py -> build/lib/refua_clinical
2026-02-17T17:10:23,410   copying src/refua_clinical/research.py -> build/lib/refua_clinical
2026-02-17T17:10:23,412   copying src/refua_clinical/protocol.py -> build/lib/refua_clinical
2026-02-17T17:10:23,414   copying src/refua_clinical/__init__.py -> build/lib/refua_clinical
2026-02-17T17:10:23,416   copying src/refua_clinical/virtual_patients.py -> build/lib/refua_clinical
2026-02-17T17:10:23,418   copying src/refua_clinical/pkpd.py -> build/lib/refua_clinical
2026-02-17T17:10:23,421   copying src/refua_clinical/estimands.py -> build/lib/refua_clinical
2026-02-17T17:10:23,423   copying src/refua_clinical/trial.py -> build/lib/refua_clinical
2026-02-17T17:10:23,425   copying src/refua_clinical/stopping.py -> build/lib/refua_clinical
2026-02-17T17:10:23,428   copying src/refua_clinical/refua_bridge.py -> build/lib/refua_clinical
2026-02-17T17:10:23,431   copying src/refua_clinical/object_api.py -> build/lib/refua_clinical
2026-02-17T17:10:23,433   copying src/refua_clinical/io.py -> build/lib/refua_clinical
2026-02-17T17:10:23,436   running egg_info
2026-02-17T17:10:23,445   writing src/refua_clinical.egg-info/PKG-INFO
2026-02-17T17:10:23,452   writing dependency_links to src/refua_clinical.egg-info/dependency_links.txt
2026-02-17T17:10:23,453   writing entry points to src/refua_clinical.egg-info/entry_points.txt
2026-02-17T17:10:23,456   writing requirements to src/refua_clinical.egg-info/requires.txt
2026-02-17T17:10:23,457   writing top-level names to src/refua_clinical.egg-info/top_level.txt
2026-02-17T17:10:23,468   reading manifest file 'src/refua_clinical.egg-info/SOURCES.txt'
2026-02-17T17:10:23,472   reading manifest template 'MANIFEST.in'
2026-02-17T17:10:23,484   adding license file 'LICENSE'
2026-02-17T17:10:23,488   writing manifest file 'src/refua_clinical.egg-info/SOURCES.txt'
2026-02-17T17:10:23,491   copying src/refua_clinical/py.typed -> build/lib/refua_clinical
2026-02-17T17:10:23,502   installing to build/bdist.linux-armv7l/wheel
2026-02-17T17:10:23,503   running install
2026-02-17T17:10:23,526   running install_lib
2026-02-17T17:10:23,531   creating build/bdist.linux-armv7l/wheel
2026-02-17T17:10:23,534   creating build/bdist.linux-armv7l/wheel/refua_clinical
2026-02-17T17:10:23,535   copying build/lib/refua_clinical/models.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,537   copying build/lib/refua_clinical/transportability.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,539   copying build/lib/refua_clinical/voi.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,541   copying build/lib/refua_clinical/admet_integration.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,543   copying build/lib/refua_clinical/cli.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,546   copying build/lib/refua_clinical/explainability.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,549   copying build/lib/refua_clinical/integrations.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,551   copying build/lib/refua_clinical/__main__.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,553   copying build/lib/refua_clinical/optimization.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,556   copying build/lib/refua_clinical/py.typed -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,558   copying build/lib/refua_clinical/research.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,560   copying build/lib/refua_clinical/protocol.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,563   copying build/lib/refua_clinical/__init__.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,565   copying build/lib/refua_clinical/virtual_patients.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,567   copying build/lib/refua_clinical/pkpd.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,569   copying build/lib/refua_clinical/estimands.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,571   copying build/lib/refua_clinical/trial.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,574   copying build/lib/refua_clinical/stopping.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,576   copying build/lib/refua_clinical/refua_bridge.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,579   copying build/lib/refua_clinical/object_api.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,582   copying build/lib/refua_clinical/io.py -> build/bdist.linux-armv7l/wheel/./refua_clinical
2026-02-17T17:10:23,584   running install_egg_info
2026-02-17T17:10:23,589   Copying src/refua_clinical.egg-info to build/bdist.linux-armv7l/wheel/./refua_clinical-0.6.0-py3.11.egg-info
2026-02-17T17:10:23,602   running install_scripts
2026-02-17T17:10:23,615   creating build/bdist.linux-armv7l/wheel/refua_clinical-0.6.0.dist-info/WHEEL
2026-02-17T17:10:23,618   creating '/tmp/pip-wheel-tj4bqv6l/.tmp-o2wi1hmk/refua_clinical-0.6.0-py3-none-any.whl' and adding 'build/bdist.linux-armv7l/wheel' to it
2026-02-17T17:10:23,621   adding 'refua_clinical/__init__.py'
2026-02-17T17:10:23,622   adding 'refua_clinical/__main__.py'
2026-02-17T17:10:23,624   adding 'refua_clinical/admet_integration.py'
2026-02-17T17:10:23,628   adding 'refua_clinical/cli.py'
2026-02-17T17:10:23,630   adding 'refua_clinical/estimands.py'
2026-02-17T17:10:23,633   adding 'refua_clinical/explainability.py'
2026-02-17T17:10:23,634   adding 'refua_clinical/integrations.py'
2026-02-17T17:10:23,636   adding 'refua_clinical/io.py'
2026-02-17T17:10:23,638   adding 'refua_clinical/models.py'
2026-02-17T17:10:23,640   adding 'refua_clinical/object_api.py'
2026-02-17T17:10:23,642   adding 'refua_clinical/optimization.py'
2026-02-17T17:10:23,643   adding 'refua_clinical/pkpd.py'
2026-02-17T17:10:23,645   adding 'refua_clinical/protocol.py'
2026-02-17T17:10:23,646   adding 'refua_clinical/py.typed'
2026-02-17T17:10:23,650   adding 'refua_clinical/refua_bridge.py'
2026-02-17T17:10:23,652   adding 'refua_clinical/research.py'
2026-02-17T17:10:23,653   adding 'refua_clinical/stopping.py'
2026-02-17T17:10:23,655   adding 'refua_clinical/transportability.py'
2026-02-17T17:10:23,657   adding 'refua_clinical/trial.py'
2026-02-17T17:10:23,659   adding 'refua_clinical/virtual_patients.py'
2026-02-17T17:10:23,660   adding 'refua_clinical/voi.py'
2026-02-17T17:10:23,663   adding 'refua_clinical-0.6.0.dist-info/licenses/LICENSE'
2026-02-17T17:10:23,665   adding 'refua_clinical-0.6.0.dist-info/METADATA'
2026-02-17T17:10:23,666   adding 'refua_clinical-0.6.0.dist-info/WHEEL'
2026-02-17T17:10:23,667   adding 'refua_clinical-0.6.0.dist-info/entry_points.txt'
2026-02-17T17:10:23,668   adding 'refua_clinical-0.6.0.dist-info/top_level.txt'
2026-02-17T17:10:23,669   adding 'refua_clinical-0.6.0.dist-info/RECORD'
2026-02-17T17:10:23,671   removing build/bdist.linux-armv7l/wheel
2026-02-17T17:10:23,779   Building wheel for refua-clinical (pyproject.toml): finished with status 'done'
2026-02-17T17:10:23,785   Created wheel for refua-clinical: filename=refua_clinical-0.6.0-py3-none-any.whl size=63613 sha256=3754ae3b13e3a8a72c35dafb8340edbe0a9610c021696c2179a5b8954685a6fc
2026-02-17T17:10:23,787   Stored in directory: /tmp/pip-ephem-wheel-cache-su7ohscd/wheels/2a/1b/f2/25c954c353c48c4761155fc2352790b7bde4dc35896daa3ef2
2026-02-17T17:10:23,800 Successfully built refua-clinical
2026-02-17T17:10:23,805 Removed build tracker: '/tmp/pip-build-tracker-vlicogt5'