2026-05-11T14:53:03,103 Created temporary directory: /tmp/pip-ephem-wheel-cache-0sesqwyv 2026-05-11T14:53:03,105 Created temporary directory: /tmp/pip-build-tracker-4u590e4e 2026-05-11T14:53:03,106 Initialized build tracking at /tmp/pip-build-tracker-4u590e4e 2026-05-11T14:53:03,106 Created build tracker: /tmp/pip-build-tracker-4u590e4e 2026-05-11T14:53:03,106 Entered build tracker: /tmp/pip-build-tracker-4u590e4e 2026-05-11T14:53:03,107 Created temporary directory: /tmp/pip-wheel-x6kdcoqe 2026-05-11T14:53:03,110 DEPRECATION: --no-binary currently disables reading from the cache of locally built wheels. In the future --no-binary will not influence the wheel cache. pip 23.1 will enforce this behaviour change. A possible replacement is to use the --no-cache-dir option. You can use the flag --use-feature=no-binary-enable-wheel-cache to test the upcoming behaviour. Discussion can be found at https://github.com/pypa/pip/issues/11453 2026-05-11T14:53:03,113 Created temporary directory: /tmp/pip-ephem-wheel-cache-_9fm9rni 2026-05-11T14:53:03,135 Looking in indexes: https://pypi.org/simple, https://www.piwheels.org/simple 2026-05-11T14:53:03,138 2 location(s) to search for versions of topiary: 2026-05-11T14:53:03,138 * https://pypi.org/simple/topiary/ 2026-05-11T14:53:03,138 * https://www.piwheels.org/simple/topiary/ 2026-05-11T14:53:03,139 Fetching project page and analyzing links: https://pypi.org/simple/topiary/ 2026-05-11T14:53:03,140 Getting page https://pypi.org/simple/topiary/ 2026-05-11T14:53:03,141 Found index url https://pypi.org/simple 2026-05-11T14:53:03,372 Fetched page https://pypi.org/simple/topiary/ as application/vnd.pypi.simple.v1+json 2026-05-11T14:53:03,393 Found link https://files.pythonhosted.org/packages/38/f6/60c60d77093e492c9a139a87514fa230296ca94080fec6d479f22bf5cfcd/topiary-0.0.0.tar.gz (from 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https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,718 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.13-py3-none-any.whl#sha256=588396661f87bea8be890d90c6800ac4825d06ae7db1c50c98a1978fe9c45bd3 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,718 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.10-py3-none-any.whl#sha256=56bea0cecf1273a44cd2e51ad294714c41e0fb7d9cc0b16382709573c4ec9443 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,719 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.9-py3-none-any.whl#sha256=da4dc4334fdf5cb89b68356e11737c8dab86fd100b9c7979e95eac3dc58fbd6d (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,720 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.8-py3-none-any.whl#sha256=12b4f283d8fbedbd316649be8833a17fee852097f1e5cd8963264e6c4a2721e0 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,720 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.7-py3-none-any.whl#sha256=6e23dbd38e19c12b658a8373b501f1e929c6fd3420749dee506a82b60b190d42 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,720 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.6-py3-none-any.whl#sha256=f3b597a0744c3a7540c3ffe571b8f4fad3d2ad40ddc6198952e2aee7c96ff82c (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,721 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.5-py3-none-any.whl#sha256=52f489eb5876b619e9988ee4c2fabec4df1a087c2f67f96cbb99ece92eb57576 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,721 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.4-py3-none-any.whl#sha256=5c94fb56e54399233efc5f88a6f6cfe2914773c5b2aa67a24f6ddf6089561b3b (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,722 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.3-py3-none-any.whl#sha256=197f9da38cd367d77acaec6282f0d22aefaf1e1ab6754379f671902958348f15 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,722 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.2-py3-none-any.whl#sha256=accaff90bafe6c929aece0f65b8ccedd45839064bf361d8f69bfefd543127ec2 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,723 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.1-py3-none-any.whl#sha256=6743a02aee34bc7567913bbe5c15a321924d9e1cb2c15f956e4ebb9b321707f4 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,723 Skipping link: No binaries permitted for topiary: https://archive1.piwheels.org/simple/topiary/topiary-0.0.0-py3-none-any.whl#sha256=a4de4e13dc8561c43fd350094d3cbc3267e0faacf5e65b94501ef15affdf51e6 (from https://www.piwheels.org/simple/topiary/) 2026-05-11T14:53:03,724 Skipping link: not a file: https://www.piwheels.org/simple/topiary/ 2026-05-11T14:53:03,725 Skipping link: not a file: https://pypi.org/simple/topiary/ 2026-05-11T14:53:03,753 Given no hashes to check 1 links for project 'topiary': discarding no candidates 2026-05-11T14:53:03,771 Collecting topiary==5.13.0 2026-05-11T14:53:03,774 Created temporary directory: /tmp/pip-unpack-fqxj5qf6 2026-05-11T14:53:04,003 Downloading topiary-5.13.0.tar.gz (230 kB) 2026-05-11T14:53:04,322 Added topiary==5.13.0 from https://files.pythonhosted.org/packages/3b/d3/34df16e51c2e59fbb337e061d8e3925c06d29b1667b71b4f99107bbf3411/topiary-5.13.0.tar.gz to build tracker '/tmp/pip-build-tracker-4u590e4e' 2026-05-11T14:53:04,327 Created temporary directory: /tmp/pip-build-env-lzrhbndg 2026-05-11T14:53:04,332 Installing build dependencies: started 2026-05-11T14:53:04,333 Running command pip subprocess to install build dependencies 2026-05-11T14:53:05,491 Using pip 23.0.1 from /usr/lib/python3/dist-packages/pip (python 3.11) 2026-05-11T14:53:05,927 DEPRECATION: --no-binary currently disables reading from the cache of locally built wheels. In the future --no-binary will not influence the wheel cache. pip 23.1 will enforce this behaviour change. A possible replacement is to use the --no-cache-dir option. You can use the flag --use-feature=no-binary-enable-wheel-cache to test the upcoming behaviour. Discussion can be found at https://github.com/pypa/pip/issues/11453 2026-05-11T14:53:05,950 Looking in indexes: https://pypi.org/simple, https://www.piwheels.org/simple 2026-05-11T14:53:07,773 Collecting setuptools>=64 2026-05-11T14:53:07,848 Using cached https://www.piwheels.org/simple/setuptools/setuptools-82.0.1-py3-none-any.whl (1.0 MB) 2026-05-11T14:53:10,789 Installing collected packages: setuptools 2026-05-11T14:53:13,905 Successfully installed setuptools-82.0.1 2026-05-11T14:53:14,173 Installing build dependencies: finished with status 'done' 2026-05-11T14:53:14,180 Getting requirements to build wheel: started 2026-05-11T14:53:14,181 Running command Getting requirements to build wheel 2026-05-11T14:53:14,874 /tmp/pip-build-env-lzrhbndg/overlay/local/lib/python3.11/dist-packages/setuptools/config/_apply_pyprojecttoml.py:61: SetuptoolsDeprecationWarning: License classifiers are deprecated. 2026-05-11T14:53:14,875 !! 2026-05-11T14:53:14,876 ******************************************************************************** 2026-05-11T14:53:14,876 Please consider removing the following classifiers in favor of a SPDX license expression: 2026-05-11T14:53:14,877 License :: OSI Approved :: Apache Software License 2026-05-11T14:53:14,879 See https://packaging.python.org/en/latest/guides/writing-pyproject-toml/#license for details. 2026-05-11T14:53:14,879 ******************************************************************************** 2026-05-11T14:53:14,880 !! 2026-05-11T14:53:14,881 dist._finalize_license_expression() 2026-05-11T14:53:14,881 /tmp/pip-build-env-lzrhbndg/overlay/local/lib/python3.11/dist-packages/setuptools/dist.py:765: SetuptoolsDeprecationWarning: License classifiers are deprecated. 2026-05-11T14:53:14,881 !! 2026-05-11T14:53:14,883 ******************************************************************************** 2026-05-11T14:53:14,883 Please consider removing the following classifiers in favor of a SPDX license expression: 2026-05-11T14:53:14,884 License :: OSI Approved :: Apache Software License 2026-05-11T14:53:14,885 See https://packaging.python.org/en/latest/guides/writing-pyproject-toml/#license for details. 2026-05-11T14:53:14,886 ******************************************************************************** 2026-05-11T14:53:14,887 !! 2026-05-11T14:53:14,887 self._finalize_license_expression() 2026-05-11T14:53:14,888 running egg_info 2026-05-11T14:53:14,891 writing topiary.egg-info/PKG-INFO 2026-05-11T14:53:14,895 writing dependency_links to topiary.egg-info/dependency_links.txt 2026-05-11T14:53:14,897 writing entry points to topiary.egg-info/entry_points.txt 2026-05-11T14:53:14,899 writing requirements to topiary.egg-info/requires.txt 2026-05-11T14:53:14,900 writing top-level names to topiary.egg-info/top_level.txt 2026-05-11T14:53:14,928 reading manifest file 'topiary.egg-info/SOURCES.txt' 2026-05-11T14:53:14,935 adding license file 'LICENSE' 2026-05-11T14:53:14,941 writing manifest file 'topiary.egg-info/SOURCES.txt' 2026-05-11T14:53:15,039 Getting requirements to build wheel: finished with status 'done' 2026-05-11T14:53:15,042 Created temporary directory: /tmp/pip-modern-metadata-mhy7x_qi 2026-05-11T14:53:15,045 Preparing metadata (pyproject.toml): started 2026-05-11T14:53:15,046 Running command Preparing metadata (pyproject.toml) 2026-05-11T14:53:15,695 /tmp/pip-build-env-lzrhbndg/overlay/local/lib/python3.11/dist-packages/setuptools/config/_apply_pyprojecttoml.py:61: SetuptoolsDeprecationWarning: License classifiers are deprecated. 2026-05-11T14:53:15,695 !! 2026-05-11T14:53:15,697 ******************************************************************************** 2026-05-11T14:53:15,697 Please consider removing the following classifiers in favor of a SPDX license expression: 2026-05-11T14:53:15,699 License :: OSI Approved :: Apache Software License 2026-05-11T14:53:15,700 See https://packaging.python.org/en/latest/guides/writing-pyproject-toml/#license for details. 2026-05-11T14:53:15,700 ******************************************************************************** 2026-05-11T14:53:15,701 !! 2026-05-11T14:53:15,702 dist._finalize_license_expression() 2026-05-11T14:53:15,702 /tmp/pip-build-env-lzrhbndg/overlay/local/lib/python3.11/dist-packages/setuptools/dist.py:765: SetuptoolsDeprecationWarning: License classifiers are deprecated. 2026-05-11T14:53:15,703 !! 2026-05-11T14:53:15,704 ******************************************************************************** 2026-05-11T14:53:15,704 Please consider removing the following classifiers in favor of a SPDX license expression: 2026-05-11T14:53:15,705 License :: OSI Approved :: Apache Software License 2026-05-11T14:53:15,706 See https://packaging.python.org/en/latest/guides/writing-pyproject-toml/#license for details. 2026-05-11T14:53:15,707 ******************************************************************************** 2026-05-11T14:53:15,708 !! 2026-05-11T14:53:15,708 self._finalize_license_expression() 2026-05-11T14:53:15,709 running dist_info 2026-05-11T14:53:15,720 creating /tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info 2026-05-11T14:53:15,721 writing /tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info/PKG-INFO 2026-05-11T14:53:15,725 writing dependency_links to /tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info/dependency_links.txt 2026-05-11T14:53:15,727 writing entry points to /tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info/entry_points.txt 2026-05-11T14:53:15,729 writing requirements to /tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info/requires.txt 2026-05-11T14:53:15,730 writing top-level names to /tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info/top_level.txt 2026-05-11T14:53:15,731 writing manifest file '/tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info/SOURCES.txt' 2026-05-11T14:53:15,757 reading manifest file '/tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info/SOURCES.txt' 2026-05-11T14:53:15,759 adding license file 'LICENSE' 2026-05-11T14:53:15,764 writing manifest file '/tmp/pip-modern-metadata-mhy7x_qi/topiary.egg-info/SOURCES.txt' 2026-05-11T14:53:15,765 creating '/tmp/pip-modern-metadata-mhy7x_qi/topiary-5.13.0.dist-info' 2026-05-11T14:53:15,891 Preparing metadata (pyproject.toml): finished with status 'done' 2026-05-11T14:53:15,898 Source in /tmp/pip-wheel-x6kdcoqe/topiary_432147a2649a4b4f8b397dfa714d905e has version 5.13.0, which satisfies requirement topiary==5.13.0 from https://files.pythonhosted.org/packages/3b/d3/34df16e51c2e59fbb337e061d8e3925c06d29b1667b71b4f99107bbf3411/topiary-5.13.0.tar.gz 2026-05-11T14:53:15,899 Removed topiary==5.13.0 from https://files.pythonhosted.org/packages/3b/d3/34df16e51c2e59fbb337e061d8e3925c06d29b1667b71b4f99107bbf3411/topiary-5.13.0.tar.gz from build tracker '/tmp/pip-build-tracker-4u590e4e' 2026-05-11T14:53:15,908 Created temporary directory: /tmp/pip-unpack-wul_d8sa 2026-05-11T14:53:15,908 Building wheels for collected packages: topiary 2026-05-11T14:53:15,913 Created temporary directory: /tmp/pip-wheel-t71z1tix 2026-05-11T14:53:15,914 Destination directory: /tmp/pip-wheel-t71z1tix 2026-05-11T14:53:15,916 Building wheel for topiary (pyproject.toml): started 2026-05-11T14:53:15,917 Running command Building wheel for topiary (pyproject.toml) 2026-05-11T14:53:16,550 /tmp/pip-build-env-lzrhbndg/overlay/local/lib/python3.11/dist-packages/setuptools/config/_apply_pyprojecttoml.py:61: SetuptoolsDeprecationWarning: License classifiers are deprecated. 2026-05-11T14:53:16,550 !! 2026-05-11T14:53:16,552 ******************************************************************************** 2026-05-11T14:53:16,553 Please consider removing the following classifiers in favor of a SPDX license expression: 2026-05-11T14:53:16,554 License :: OSI Approved :: Apache Software License 2026-05-11T14:53:16,555 See https://packaging.python.org/en/latest/guides/writing-pyproject-toml/#license for details. 2026-05-11T14:53:16,556 ******************************************************************************** 2026-05-11T14:53:16,557 !! 2026-05-11T14:53:16,557 dist._finalize_license_expression() 2026-05-11T14:53:16,558 /tmp/pip-build-env-lzrhbndg/overlay/local/lib/python3.11/dist-packages/setuptools/dist.py:765: SetuptoolsDeprecationWarning: License classifiers are deprecated. 2026-05-11T14:53:16,558 !! 2026-05-11T14:53:16,559 ******************************************************************************** 2026-05-11T14:53:16,560 Please consider removing the following classifiers in favor of a SPDX license expression: 2026-05-11T14:53:16,561 License :: OSI Approved :: Apache Software License 2026-05-11T14:53:16,564 See https://packaging.python.org/en/latest/guides/writing-pyproject-toml/#license for details. 2026-05-11T14:53:16,567 ******************************************************************************** 2026-05-11T14:53:16,568 !! 2026-05-11T14:53:16,569 self._finalize_license_expression() 2026-05-11T14:53:16,570 running bdist_wheel 2026-05-11T14:53:16,579 running build 2026-05-11T14:53:16,580 running build_py 2026-05-11T14:53:16,587 creating build/lib/topiary 2026-05-11T14:53:16,589 copying topiary/filters.py -> build/lib/topiary 2026-05-11T14:53:16,592 copying topiary/self_proteome.py -> build/lib/topiary 2026-05-11T14:53:16,595 copying topiary/io.py -> build/lib/topiary 2026-05-11T14:53:16,598 copying topiary/properties.py -> build/lib/topiary 2026-05-11T14:53:16,601 copying topiary/wide.py -> build/lib/topiary 2026-05-11T14:53:16,604 copying topiary/inputs.py -> build/lib/topiary 2026-05-11T14:53:16,607 copying topiary/io_lens.py -> build/lib/topiary 2026-05-11T14:53:16,609 copying topiary/result.py -> build/lib/topiary 2026-05-11T14:53:16,612 copying topiary/predictor.py -> build/lib/topiary 2026-05-11T14:53:16,615 copying topiary/protein_fragment.py -> build/lib/topiary 2026-05-11T14:53:16,618 copying topiary/io_protein_fragment.py -> build/lib/topiary 2026-05-11T14:53:16,621 copying topiary/cached.py -> build/lib/topiary 2026-05-11T14:53:16,625 copying topiary/sequence_helpers.py -> build/lib/topiary 2026-05-11T14:53:16,627 copying topiary/__init__.py -> build/lib/topiary 2026-05-11T14:53:16,630 copying topiary/sources.py -> build/lib/topiary 2026-05-11T14:53:16,634 creating build/lib/tests 2026-05-11T14:53:16,636 copying tests/test_padding.py -> build/lib/tests 2026-05-11T14:53:16,638 copying tests/test_rna_helpers.py -> build/lib/tests 2026-05-11T14:53:16,641 copying tests/test_lazy_imports.py -> build/lib/tests 2026-05-11T14:53:16,643 copying tests/test_io_lens.py -> build/lib/tests 2026-05-11T14:53:16,646 copying tests/test_load_stringtie_gtf_fpkm.py -> build/lib/tests 2026-05-11T14:53:16,648 copying tests/test_predict_from_variants_refactor.py -> build/lib/tests 2026-05-11T14:53:16,651 copying tests/test_cli_script.py -> build/lib/tests 2026-05-11T14:53:16,653 copying tests/test_self_proteome.py -> build/lib/tests 2026-05-11T14:53:16,656 copying tests/test_args_outputs.py -> build/lib/tests 2026-05-11T14:53:16,658 copying tests/test_direct_input_regressions.py -> build/lib/tests 2026-05-11T14:53:16,661 copying tests/test_expression_integration.py -> build/lib/tests 2026-05-11T14:53:16,663 copying tests/test_epitopes_from_commandline_args.py -> build/lib/tests 2026-05-11T14:53:16,665 copying tests/test_kind_support.py -> build/lib/tests 2026-05-11T14:53:16,668 copying tests/test_cli_coverage.py -> build/lib/tests 2026-05-11T14:53:16,671 copying tests/test_mutant_epitope_predictions_class2.py -> build/lib/tests 2026-05-11T14:53:16,673 copying tests/test_frameshift_fragments.py -> build/lib/tests 2026-05-11T14:53:16,676 copying tests/test_contains_mutant_residues.py -> build/lib/tests 2026-05-11T14:53:16,679 copying tests/test_result.py -> build/lib/tests 2026-05-11T14:53:16,682 copying tests/test_io.py -> build/lib/tests 2026-05-11T14:53:16,685 copying tests/test_edge_case_fixtures.py -> build/lib/tests 2026-05-11T14:53:16,688 copying tests/test_cli_cached_predictor.py -> build/lib/tests 2026-05-11T14:53:16,690 copying tests/test_cli_protein_changes.py -> build/lib/tests 2026-05-11T14:53:16,693 copying tests/test_load_cufflinks_fpkm.py -> build/lib/tests 2026-05-11T14:53:16,695 copying tests/test_dsl_roundtrip.py -> build/lib/tests 2026-05-11T14:53:16,698 copying tests/test_dsl_polish.py -> build/lib/tests 2026-05-11T14:53:16,701 copying tests/test_coverage_gaps.py -> build/lib/tests 2026-05-11T14:53:16,704 copying tests/test_sequence_helpers.py -> build/lib/tests 2026-05-11T14:53:16,706 copying tests/test_cli_ranking.py -> build/lib/tests 2026-05-11T14:53:16,709 copying tests/data.py -> build/lib/tests 2026-05-11T14:53:16,711 copying tests/test_best_allele.py -> build/lib/tests 2026-05-11T14:53:16,714 copying tests/test_expression_loader.py -> build/lib/tests 2026-05-11T14:53:16,717 copying tests/test_end_to_end.py -> build/lib/tests 2026-05-11T14:53:16,720 copying tests/test_inputs.py -> build/lib/tests 2026-05-11T14:53:16,722 copying tests/test_mutant_epitope_predictions_class1.py -> build/lib/tests 2026-05-11T14:53:16,725 copying tests/test_protein_fragment.py -> build/lib/tests 2026-05-11T14:53:16,728 copying tests/test_dsl_extensions.py -> build/lib/tests 2026-05-11T14:53:16,731 copying tests/common.py -> build/lib/tests 2026-05-11T14:53:16,733 copying tests/test_sources.py -> build/lib/tests 2026-05-11T14:53:16,736 copying tests/test_effect_expression_filters.py -> build/lib/tests 2026-05-11T14:53:16,738 copying tests/test_cached_predictor.py -> build/lib/tests 2026-05-11T14:53:16,741 copying tests/test_variant_expression_filters.py -> build/lib/tests 2026-05-11T14:53:16,744 copying tests/test_predict_from_fragments.py -> build/lib/tests 2026-05-11T14:53:16,747 copying tests/test_dataframe.py -> build/lib/tests 2026-05-11T14:53:16,749 copying tests/test_ranking.py -> build/lib/tests 2026-05-11T14:53:16,754 copying tests/test_deploy_script.py -> build/lib/tests 2026-05-11T14:53:16,756 copying tests/test_integration.py -> build/lib/tests 2026-05-11T14:53:16,759 copying tests/__init__.py -> build/lib/tests 2026-05-11T14:53:16,761 copying tests/test_predictor_internals.py -> build/lib/tests 2026-05-11T14:53:16,764 copying tests/test_validation_and_edge_cases.py -> build/lib/tests 2026-05-11T14:53:16,766 copying tests/test_sources_optional.py -> build/lib/tests 2026-05-11T14:53:16,768 copying tests/test_wide.py -> build/lib/tests 2026-05-11T14:53:16,772 copying tests/test_peptide_mutation_interval.py -> build/lib/tests 2026-05-11T14:53:16,775 creating build/lib/topiary/ranking 2026-05-11T14:53:16,776 copying topiary/ranking/parser.py -> build/lib/topiary/ranking 2026-05-11T14:53:16,779 copying topiary/ranking/apply.py -> build/lib/topiary/ranking 2026-05-11T14:53:16,782 copying topiary/ranking/nodes.py -> build/lib/topiary/ranking 2026-05-11T14:53:16,787 copying topiary/ranking/__init__.py -> build/lib/topiary/ranking 2026-05-11T14:53:16,789 creating build/lib/topiary/rna 2026-05-11T14:53:16,791 copying topiary/rna/gtf.py -> build/lib/topiary/rna 2026-05-11T14:53:16,793 copying topiary/rna/common.py -> build/lib/topiary/rna 2026-05-11T14:53:16,796 copying topiary/rna/expression_loader.py -> build/lib/topiary/rna 2026-05-11T14:53:16,798 copying topiary/rna/cufflinks.py -> build/lib/topiary/rna 2026-05-11T14:53:16,801 copying topiary/rna/__init__.py -> build/lib/topiary/rna 2026-05-11T14:53:16,804 creating build/lib/topiary/cli 2026-05-11T14:53:16,806 copying topiary/cli/script.py -> build/lib/topiary/cli 2026-05-11T14:53:16,808 copying topiary/cli/filtering.py -> build/lib/topiary/cli 2026-05-11T14:53:16,811 copying topiary/cli/sequence.py -> build/lib/topiary/cli 2026-05-11T14:53:16,813 copying topiary/cli/args.py -> build/lib/topiary/cli 2026-05-11T14:53:16,816 copying topiary/cli/protein_changes.py -> build/lib/topiary/cli 2026-05-11T14:53:16,819 copying topiary/cli/cached_predictor.py -> build/lib/topiary/cli 2026-05-11T14:53:16,822 copying topiary/cli/rna.py -> build/lib/topiary/cli 2026-05-11T14:53:16,825 copying topiary/cli/errors.py -> build/lib/topiary/cli 2026-05-11T14:53:16,827 copying topiary/cli/__init__.py -> build/lib/topiary/cli 2026-05-11T14:53:16,829 copying topiary/cli/outputs.py -> build/lib/topiary/cli 2026-05-11T14:53:16,831 running egg_info 2026-05-11T14:53:16,841 writing topiary.egg-info/PKG-INFO 2026-05-11T14:53:16,846 writing dependency_links to topiary.egg-info/dependency_links.txt 2026-05-11T14:53:16,848 writing entry points to topiary.egg-info/entry_points.txt 2026-05-11T14:53:16,849 writing requirements to topiary.egg-info/requires.txt 2026-05-11T14:53:16,851 writing top-level names to topiary.egg-info/top_level.txt 2026-05-11T14:53:16,868 reading manifest file 'topiary.egg-info/SOURCES.txt' 2026-05-11T14:53:16,875 adding license file 'LICENSE' 2026-05-11T14:53:16,882 writing manifest file 'topiary.egg-info/SOURCES.txt' 2026-05-11T14:53:16,900 installing to build/bdist.linux-armv7l/wheel 2026-05-11T14:53:16,901 running install 2026-05-11T14:53:16,925 running install_lib 2026-05-11T14:53:16,931 creating build/bdist.linux-armv7l/wheel 2026-05-11T14:53:16,934 creating build/bdist.linux-armv7l/wheel/topiary 2026-05-11T14:53:16,935 copying build/lib/topiary/filters.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,938 copying build/lib/topiary/self_proteome.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,942 copying build/lib/topiary/io.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,945 copying build/lib/topiary/properties.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,947 copying build/lib/topiary/wide.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,950 copying build/lib/topiary/inputs.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,954 creating build/bdist.linux-armv7l/wheel/topiary/ranking 2026-05-11T14:53:16,955 copying build/lib/topiary/ranking/parser.py -> build/bdist.linux-armv7l/wheel/./topiary/ranking 2026-05-11T14:53:16,958 copying build/lib/topiary/ranking/apply.py -> build/bdist.linux-armv7l/wheel/./topiary/ranking 2026-05-11T14:53:16,961 copying build/lib/topiary/ranking/nodes.py -> build/bdist.linux-armv7l/wheel/./topiary/ranking 2026-05-11T14:53:16,966 copying build/lib/topiary/ranking/__init__.py -> build/bdist.linux-armv7l/wheel/./topiary/ranking 2026-05-11T14:53:16,969 creating build/bdist.linux-armv7l/wheel/topiary/rna 2026-05-11T14:53:16,970 copying build/lib/topiary/rna/gtf.py -> build/bdist.linux-armv7l/wheel/./topiary/rna 2026-05-11T14:53:16,973 copying build/lib/topiary/rna/common.py -> build/bdist.linux-armv7l/wheel/./topiary/rna 2026-05-11T14:53:16,976 copying build/lib/topiary/rna/expression_loader.py -> build/bdist.linux-armv7l/wheel/./topiary/rna 2026-05-11T14:53:16,979 copying build/lib/topiary/rna/cufflinks.py -> build/bdist.linux-armv7l/wheel/./topiary/rna 2026-05-11T14:53:16,981 copying build/lib/topiary/rna/__init__.py -> build/bdist.linux-armv7l/wheel/./topiary/rna 2026-05-11T14:53:16,984 copying build/lib/topiary/io_lens.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,987 copying build/lib/topiary/result.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,990 copying build/lib/topiary/predictor.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,993 copying build/lib/topiary/protein_fragment.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:16,997 copying build/lib/topiary/io_protein_fragment.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:17,000 copying build/lib/topiary/cached.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:17,003 copying build/lib/topiary/sequence_helpers.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:17,007 creating build/bdist.linux-armv7l/wheel/topiary/cli 2026-05-11T14:53:17,008 copying build/lib/topiary/cli/script.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,011 copying build/lib/topiary/cli/filtering.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,014 copying build/lib/topiary/cli/sequence.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,016 copying build/lib/topiary/cli/args.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,019 copying build/lib/topiary/cli/protein_changes.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,021 copying build/lib/topiary/cli/cached_predictor.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,024 copying build/lib/topiary/cli/rna.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,027 copying build/lib/topiary/cli/errors.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,029 copying build/lib/topiary/cli/__init__.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,031 copying build/lib/topiary/cli/outputs.py -> build/bdist.linux-armv7l/wheel/./topiary/cli 2026-05-11T14:53:17,034 copying build/lib/topiary/__init__.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:17,036 copying build/lib/topiary/sources.py -> build/bdist.linux-armv7l/wheel/./topiary 2026-05-11T14:53:17,040 creating build/bdist.linux-armv7l/wheel/tests 2026-05-11T14:53:17,042 copying build/lib/tests/test_padding.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,044 copying build/lib/tests/test_rna_helpers.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,046 copying build/lib/tests/test_lazy_imports.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,048 copying build/lib/tests/test_io_lens.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,051 copying build/lib/tests/test_load_stringtie_gtf_fpkm.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,053 copying build/lib/tests/test_predict_from_variants_refactor.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,056 copying build/lib/tests/test_cli_script.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,058 copying build/lib/tests/test_self_proteome.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,061 copying build/lib/tests/test_args_outputs.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,063 copying build/lib/tests/test_direct_input_regressions.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,065 copying build/lib/tests/test_expression_integration.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,067 copying build/lib/tests/test_epitopes_from_commandline_args.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,069 copying build/lib/tests/test_kind_support.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,071 copying build/lib/tests/test_cli_coverage.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,074 copying build/lib/tests/test_mutant_epitope_predictions_class2.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,076 copying build/lib/tests/test_frameshift_fragments.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,078 copying build/lib/tests/test_contains_mutant_residues.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,080 copying build/lib/tests/test_result.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,083 copying build/lib/tests/test_io.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,086 copying build/lib/tests/test_edge_case_fixtures.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,088 copying build/lib/tests/test_cli_cached_predictor.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,090 copying build/lib/tests/test_cli_protein_changes.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,092 copying build/lib/tests/test_load_cufflinks_fpkm.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,094 copying build/lib/tests/test_dsl_roundtrip.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,097 copying build/lib/tests/test_dsl_polish.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,100 copying build/lib/tests/test_coverage_gaps.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,102 copying build/lib/tests/test_sequence_helpers.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,104 copying build/lib/tests/test_cli_ranking.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,106 copying build/lib/tests/data.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,108 copying build/lib/tests/test_best_allele.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,111 copying build/lib/tests/test_expression_loader.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,113 copying build/lib/tests/test_end_to_end.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,116 copying build/lib/tests/test_inputs.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,118 copying build/lib/tests/test_mutant_epitope_predictions_class1.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,120 copying build/lib/tests/test_protein_fragment.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,122 copying build/lib/tests/test_dsl_extensions.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,125 copying build/lib/tests/common.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,127 copying build/lib/tests/test_sources.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,129 copying build/lib/tests/test_effect_expression_filters.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,131 copying build/lib/tests/test_cached_predictor.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,134 copying build/lib/tests/test_variant_expression_filters.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,136 copying build/lib/tests/test_predict_from_fragments.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,139 copying build/lib/tests/test_dataframe.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,141 copying build/lib/tests/test_ranking.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,146 copying build/lib/tests/test_deploy_script.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,148 copying build/lib/tests/test_integration.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,150 copying build/lib/tests/__init__.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,151 copying build/lib/tests/test_predictor_internals.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,154 copying build/lib/tests/test_validation_and_edge_cases.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,156 copying build/lib/tests/test_sources_optional.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,159 copying build/lib/tests/test_wide.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,161 copying build/lib/tests/test_peptide_mutation_interval.py -> build/bdist.linux-armv7l/wheel/./tests 2026-05-11T14:53:17,163 running install_egg_info 2026-05-11T14:53:17,168 Copying topiary.egg-info to build/bdist.linux-armv7l/wheel/./topiary-5.13.0-py3.11.egg-info 2026-05-11T14:53:17,181 running install_scripts 2026-05-11T14:53:17,195 creating build/bdist.linux-armv7l/wheel/topiary-5.13.0.dist-info/WHEEL 2026-05-11T14:53:17,197 creating '/tmp/pip-wheel-t71z1tix/.tmp-9vhml4nd/topiary-5.13.0-py3-none-any.whl' and adding 'build/bdist.linux-armv7l/wheel' to it 2026-05-11T14:53:17,200 adding 'tests/__init__.py' 2026-05-11T14:53:17,202 adding 'tests/common.py' 2026-05-11T14:53:17,204 adding 'tests/data.py' 2026-05-11T14:53:17,205 adding 'tests/test_args_outputs.py' 2026-05-11T14:53:17,207 adding 'tests/test_best_allele.py' 2026-05-11T14:53:17,212 adding 'tests/test_cached_predictor.py' 2026-05-11T14:53:17,214 adding 'tests/test_cli_cached_predictor.py' 2026-05-11T14:53:17,216 adding 'tests/test_cli_coverage.py' 2026-05-11T14:53:17,217 adding 'tests/test_cli_protein_changes.py' 2026-05-11T14:53:17,219 adding 'tests/test_cli_ranking.py' 2026-05-11T14:53:17,221 adding 'tests/test_cli_script.py' 2026-05-11T14:53:17,222 adding 'tests/test_contains_mutant_residues.py' 2026-05-11T14:53:17,224 adding 'tests/test_coverage_gaps.py' 2026-05-11T14:53:17,225 adding 'tests/test_dataframe.py' 2026-05-11T14:53:17,226 adding 'tests/test_deploy_script.py' 2026-05-11T14:53:17,228 adding 'tests/test_direct_input_regressions.py' 2026-05-11T14:53:17,230 adding 'tests/test_dsl_extensions.py' 2026-05-11T14:53:17,232 adding 'tests/test_dsl_polish.py' 2026-05-11T14:53:17,235 adding 'tests/test_dsl_roundtrip.py' 2026-05-11T14:53:17,237 adding 'tests/test_edge_case_fixtures.py' 2026-05-11T14:53:17,238 adding 'tests/test_effect_expression_filters.py' 2026-05-11T14:53:17,240 adding 'tests/test_end_to_end.py' 2026-05-11T14:53:17,241 adding 'tests/test_epitopes_from_commandline_args.py' 2026-05-11T14:53:17,243 adding 'tests/test_expression_integration.py' 2026-05-11T14:53:17,244 adding 'tests/test_expression_loader.py' 2026-05-11T14:53:17,247 adding 'tests/test_frameshift_fragments.py' 2026-05-11T14:53:17,248 adding 'tests/test_inputs.py' 2026-05-11T14:53:17,250 adding 'tests/test_integration.py' 2026-05-11T14:53:17,252 adding 'tests/test_io.py' 2026-05-11T14:53:17,254 adding 'tests/test_io_lens.py' 2026-05-11T14:53:17,256 adding 'tests/test_kind_support.py' 2026-05-11T14:53:17,257 adding 'tests/test_lazy_imports.py' 2026-05-11T14:53:17,258 adding 'tests/test_load_cufflinks_fpkm.py' 2026-05-11T14:53:17,260 adding 'tests/test_load_stringtie_gtf_fpkm.py' 2026-05-11T14:53:17,261 adding 'tests/test_mutant_epitope_predictions_class1.py' 2026-05-11T14:53:17,263 adding 'tests/test_mutant_epitope_predictions_class2.py' 2026-05-11T14:53:17,264 adding 'tests/test_padding.py' 2026-05-11T14:53:17,265 adding 'tests/test_peptide_mutation_interval.py' 2026-05-11T14:53:17,268 adding 'tests/test_predict_from_fragments.py' 2026-05-11T14:53:17,271 adding 'tests/test_predict_from_variants_refactor.py' 2026-05-11T14:53:17,272 adding 'tests/test_predictor_internals.py' 2026-05-11T14:53:17,275 adding 'tests/test_protein_fragment.py' 2026-05-11T14:53:17,284 adding 'tests/test_ranking.py' 2026-05-11T14:53:17,287 adding 'tests/test_result.py' 2026-05-11T14:53:17,289 adding 'tests/test_rna_helpers.py' 2026-05-11T14:53:17,292 adding 'tests/test_self_proteome.py' 2026-05-11T14:53:17,293 adding 'tests/test_sequence_helpers.py' 2026-05-11T14:53:17,295 adding 'tests/test_sources.py' 2026-05-11T14:53:17,296 adding 'tests/test_sources_optional.py' 2026-05-11T14:53:17,298 adding 'tests/test_validation_and_edge_cases.py' 2026-05-11T14:53:17,300 adding 'tests/test_variant_expression_filters.py' 2026-05-11T14:53:17,302 adding 'tests/test_wide.py' 2026-05-11T14:53:17,304 adding 'topiary/__init__.py' 2026-05-11T14:53:17,310 adding 'topiary/cached.py' 2026-05-11T14:53:17,312 adding 'topiary/filters.py' 2026-05-11T14:53:17,314 adding 'topiary/inputs.py' 2026-05-11T14:53:17,316 adding 'topiary/io.py' 2026-05-11T14:53:17,318 adding 'topiary/io_lens.py' 2026-05-11T14:53:17,320 adding 'topiary/io_protein_fragment.py' 2026-05-11T14:53:17,325 adding 'topiary/predictor.py' 2026-05-11T14:53:17,327 adding 'topiary/properties.py' 2026-05-11T14:53:17,330 adding 'topiary/protein_fragment.py' 2026-05-11T14:53:17,332 adding 'topiary/result.py' 2026-05-11T14:53:17,336 adding 'topiary/self_proteome.py' 2026-05-11T14:53:17,338 adding 'topiary/sequence_helpers.py' 2026-05-11T14:53:17,340 adding 'topiary/sources.py' 2026-05-11T14:53:17,342 adding 'topiary/wide.py' 2026-05-11T14:53:17,344 adding 'topiary/cli/__init__.py' 2026-05-11T14:53:17,347 adding 'topiary/cli/args.py' 2026-05-11T14:53:17,349 adding 'topiary/cli/cached_predictor.py' 2026-05-11T14:53:17,351 adding 'topiary/cli/errors.py' 2026-05-11T14:53:17,352 adding 'topiary/cli/filtering.py' 2026-05-11T14:53:17,354 adding 'topiary/cli/outputs.py' 2026-05-11T14:53:17,355 adding 'topiary/cli/protein_changes.py' 2026-05-11T14:53:17,357 adding 'topiary/cli/rna.py' 2026-05-11T14:53:17,358 adding 'topiary/cli/script.py' 2026-05-11T14:53:17,359 adding 'topiary/cli/sequence.py' 2026-05-11T14:53:17,361 adding 'topiary/ranking/__init__.py' 2026-05-11T14:53:17,363 adding 'topiary/ranking/apply.py' 2026-05-11T14:53:17,371 adding 'topiary/ranking/nodes.py' 2026-05-11T14:53:17,374 adding 'topiary/ranking/parser.py' 2026-05-11T14:53:17,376 adding 'topiary/rna/__init__.py' 2026-05-11T14:53:17,378 adding 'topiary/rna/common.py' 2026-05-11T14:53:17,379 adding 'topiary/rna/cufflinks.py' 2026-05-11T14:53:17,381 adding 'topiary/rna/expression_loader.py' 2026-05-11T14:53:17,383 adding 'topiary/rna/gtf.py' 2026-05-11T14:53:17,386 adding 'topiary-5.13.0.dist-info/licenses/LICENSE' 2026-05-11T14:53:17,389 adding 'topiary-5.13.0.dist-info/METADATA' 2026-05-11T14:53:17,391 adding 'topiary-5.13.0.dist-info/WHEEL' 2026-05-11T14:53:17,392 adding 'topiary-5.13.0.dist-info/entry_points.txt' 2026-05-11T14:53:17,393 adding 'topiary-5.13.0.dist-info/top_level.txt' 2026-05-11T14:53:17,395 adding 'topiary-5.13.0.dist-info/RECORD' 2026-05-11T14:53:17,402 removing build/bdist.linux-armv7l/wheel 2026-05-11T14:53:17,524 Building wheel for topiary (pyproject.toml): finished with status 'done' 2026-05-11T14:53:17,534 Created wheel for topiary: filename=topiary-5.13.0-py3-none-any.whl size=258719 sha256=ee7ecd6f409d0af411c680abb0c34bd56094fd40b432853e379d061fd8914250 2026-05-11T14:53:17,535 Stored in directory: /tmp/pip-ephem-wheel-cache-_9fm9rni/wheels/94/3c/de/c012147d2a4ba6881a3f1c1480f5ae4ca3b122941f46b608e1 2026-05-11T14:53:17,553 Successfully built topiary 2026-05-11T14:53:17,563 Removed build tracker: '/tmp/pip-build-tracker-4u590e4e'